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What treats psoriasis when creams are not enough?

Psoriasis is a long-lasting immune condition that builds thick, scaly patches on the skin, and for some people it also affects the nails and joints. Mild psoriasis often responds to creams and ointments, and when it does not, dermatologists move to light therapy and to medicines that work through the whole body.

Dr. Victoria Taraska Medically reviewed by dermatologist Dr. Victoria Taraska, MD, FAAD, FRCPC

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Psoriasis is a long-lasting condition in which the immune system becomes overactive. The result is thick, red, raised patches, often covered with silvery-white scale, that may itch or burn. It affects nearly 7.5 million people in the United States, men and women equally. It is seen mainly in adults, most often between 45 and 64, though children get it too. It is not contagious.

Psoriasis cycles between flares and calmer periods. There is no cure yet, which is why the goal of treatment is control rather than a one-time fix.

What it looks like and what sets it off

About 80 to 90% of people with psoriasis have the plaque type: raised patches, usually on the scalp, elbows, knees and lower back. They often itch, and scratching can make them thicker. Other types look different. Guttate psoriasis shows as many small, scaly spots that appear suddenly, often after strep throat. Inverse psoriasis forms smooth, red, raw-looking patches where skin touches skin. Pustular psoriasis brings pus-filled bumps, usually on the hands and feet.

Psoriasis can look different on darker skin. Instead of red or pink, the patches often look violet or dark brown, and the scale can look gray, which can make psoriasis harder to recognize.

About half of people with plaque psoriasis get nail changes at some point: tiny pits, white, yellow or brown discoloration, crumbling, or nails lifting off the nail bed.

Common triggers include stress, skin injuries, infections such as strep, smoking, heavy or frequent drinking, dry cold weather, sunburn, and some medicines. A cut, scrape, sunburn or bug bite can set off a flare near or in the same spot, and tattoos, piercings and shaving nicks are on the trigger list for the same reason. Excess weight makes symptoms worse.

When to see a dermatologist

  • Dry, thick, raised patches that do not clear up.
  • Psoriasis that is getting worse, or not improving with the treatment you are using.
  • A swollen, tender finger or toe joint, heel pain, or stiffness in the morning that fades as the day goes on. These are early signs of psoriatic arthritis, which develops in about 1 in 3 people with psoriasis and can cause lasting joint damage if left untreated.

Skin that looks burnt over most of the body, with chills, fever or a racing pulse, can be erythrodermic psoriasis. Widespread pus-filled bumps with fever can be generalized pustular psoriasis. Both are rare, and both need emergency care.

What happens at the visit

A dermatologist examines the skin, scalp and nails and asks about itching or burning, recent illness or stress, the medicines you take, relatives with psoriasis, and any joint pain. When the diagnosis is unclear, they may take a small skin sample to look at under a microscope, which rules out conditions that look similar. Bring a list of everything you take, since some medicines can trigger flares.

How dermatologists treat it

Treatment depends on the type of psoriasis, how severe it is, where it is on the body, and the side effects a person can accept.

  • Topical medicines. Creams, ointments, and medicated shampoos for the scalp, often including a corticosteroid, along with vitamin D-based medicines, retinoids and coal tar. Newer non-steroid creams include roflumilast (Zoryve), which calms inflammation by blocking an enzyme called PDE4, and tapinarof (Vtama in the United States, Nduvra in Canada), which works on the same skin pathway as coal tar. Topical JAK inhibitor creams are also used for psoriasis in some cases. These are the usual start for mild to moderate psoriasis.
  • Light therapy. Controlled ultraviolet light given in the office, or with a prescribed home unit, usually when large areas of skin are involved or symptoms have not improved with creams.
  • Systemic medicines. Pills and other medicines that work through the whole body, used for more severe psoriasis.
  • Biologics. Injected medicines that block specific immune signals, which helps decrease or stop the inflammation.

If a medicine prescribed for something else seems to be causing flares, the American Academy of Dermatology advises raising it with the doctor who prescribed it rather than changing it alone.

Living with it day to day

Short, lukewarm baths or showers, mild soap, and a heavy moisturizer applied while the skin is still damp all help. So does a humidifier in dry, cold months. Keeping a healthy weight, not smoking, and limiting alcohol are part of the standard self-care advice, since obesity worsens symptoms and some studies link alcohol to worse psoriasis. A little sunlight can help some people, but sunburn triggers flares, so ask the dermatologist how much is right. Psoriasis can weigh on mood, and counseling is a normal part of care.

How to choose a dermatologist

Ask how much of the practice is psoriasis care and whether they offer light therapy on site. Ask how they check for psoriatic arthritis and whether they work with a rheumatologist. Ask what comes next if creams do not work. Check whether your insurance needs a referral, and whether newer medicines need prior approval from your plan.

The city list below shows dermatologists who name psoriasis on their own websites.

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Dermatologists

Dermatologists who name psoriasis on their own websites

1,112 dermatology practices in 123 cities list psoriasis among the conditions they treat. Pick a city to see them, filtered to psoriasis. Contact the practice directly: ask whether you need a referral and how your insurance applies.

FAQ

Psoriasis: common questions

Is psoriasis contagious?

No. Psoriasis comes from an overactive immune system, with genes and environment both involved. It cannot be caught from touching someone or sharing a towel.

Can psoriasis go away?

There is no cure yet. Psoriasis does cycle between flares and calmer periods, and treatment can control the symptoms. Managing triggers such as stress, skin injuries, smoking and infections also helps keep flares down.

Why does a dermatologist ask about my joints?

About 1 in 3 people with psoriasis go on to develop psoriatic arthritis, and it usually follows the skin symptoms by years. Early signs are easy to miss: a swollen, tender finger or toe, heel pain, or stiffness in the morning that eases during the day. Untreated, it can cause lasting joint damage, which is why the visit includes questions about joint pain.

Is psoriasis just a skin problem?

Not entirely. Psoriasis is linked with a higher risk of psoriatic arthritis, diabetes, heart attack and stroke, and anxiety and depression. That is one reason the visit covers more than the skin, and why some people see a rheumatologist or a mental health professional alongside their dermatologist.

Sources

Where this information comes from

Clinical facts on this page are checked against these primary sources.

  1. 1.Do people of color get psoriasis?, American Academy of DermatologyConfirms that on darker skin psoriasis often looks violet with gray scale, and on dark skin can be dark brown and difficult to see, backing this page's line on how psoriasis looks on skin of color.
  2. 2.ZORYVE (roflumilast) cream: prescribing information, DailyMed, U.S. National Library of MedicineConfirms roflumilast cream is indicated for plaque psoriasis, including skin folds, in adults and children 2 and older, and that roflumilast is a PDE4 inhibitor, backing this page's topical treatment list.
  3. 3.Health Canada approves NDUVRA (tapinarof cream), 1%, Organon CanadaConfirms tapinarof 1% cream is approved in Canada as NDUVRA for the topical treatment of plaque psoriasis in adults, is known as VTAMA outside Canada, and is an aryl hydrocarbon receptor agonist, backing this page's topical treatment list.
  4. 4.Skin conditions by the numbers, American Academy of DermatologyConfirms psoriasis affects nearly 7.5 million people in the United States and is seen mainly in adults, most often between ages 45 and 64, backing this page's opening prevalence and age statements.
  5. 5.Psoriasis, Cleveland ClinicConfirms psoriasis is not contagious, that more than 3% of the US population has it, that about 1 in 3 people diagnosed with psoriasis will also develop arthritis, that a provider can diagnose it from a skin exam and history and may take a biopsy when the diagnosis is unclear, and suggests questions to ask a provider such as what the options are if creams do not work, backing this page's contagion and joint statements and its choosing-a-dermatologist questions.
  6. 6.Psoriasis, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH)Confirms psoriasis is a chronic disease in which the immune system becomes overactive, involving genetic and environmental factors, that it affects men and women equally and is more common in adults, that symptoms cycle between flares and remission, that patches are thick, red and covered with silvery-white scales that may itch or burn, describes the plaque, guttate, pustular, inverse and erythrodermic types, lists triggers and risk factors including infections such as strep, certain medicines, smoking, obesity, stress and skin injury, and links psoriasis with psoriatic arthritis, heart attack and stroke, diabetes, anxiety and depression, backing this page's description, types, triggers and related-conditions sections.
  7. 7.Psoriasis: Diagnosis, Treatment, and Steps to Take, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH)Confirms a doctor examines the skin, scalp and nails and asks about itching or burning, recent illness or stress, medicines, relatives with psoriasis and joint tenderness, may take a small skin sample to rule out lookalikes, that there is no cure, that topical treatments are commonly used for mild to moderate disease, phototherapy when large areas are affected, systemic medicines for more severe cases and biologics that block specific immune molecules, that self-care includes lukewarm water, mild soap and heavy moisturizer on damp skin, a healthy weight, quitting smoking, limiting alcohol and only small amounts of sun, and that dermatologists, rheumatologists, mental health professionals and primary care providers treat it, backing this page's visit, treatment and day-to-day sections.
  8. 8.Psoriasis: Signs and symptoms, American Academy of DermatologyConfirms plaque psoriasis accounts for about 80 to 90% of cases and usually appears on the scalp, elbows, knees or lower back, that scratching can thicken patches, that guttate psoriasis appears suddenly as small scaly bumps and tends to follow infections such as strep throat, that inverse psoriasis forms smooth raw-looking patches where skin touches skin and pustular psoriasis brings pus-filled bumps usually on the hands and feet, that generalized pustular psoriasis with fever is rare and serious, that about half of people with plaque psoriasis get nail signs such as pits, discoloration and lifting, that early psoriatic arthritis signs include a swollen tender finger or toe joint, heel pain and morning stiffness that fades during the day, that people should see a dermatologist if psoriasis is worsening or not improving with treatment, and that erythrodermic psoriasis (skin that looks burnt over most of the body, with chills, fever and rapid pulse) needs immediate medical attention, backing this page's appearance and when-to-see-a-dermatologist sections.
  9. 9.Psoriasis: Flare-ups due to triggers, American Academy of DermatologyConfirms common psoriasis triggers include stress, skin injury, frequent or heavy drinking, smoking, dry cold weather, sunburn, infection, certain medications, tattoos and piercings and shaving cuts, that a skin injury can cause a flare in the same spot, and that if a medication seems to cause flares the advice is to ask the prescribing doctor rather than stop it, backing this page's trigger list and its note on medicines.

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ClinicCompass. (2026). What treats psoriasis when creams are not enough? Medically reviewed by Victoria Taraska, MD, FAAD, FRCPC. Retrieved {accessed}, from https://thecliniccompass.com/concerns/psoriasis/