The newest neuromodulator, formulated with a peptide instead of animal-derived proteins and approved on trials showing results lasting around six months for many patients, roughly twice the typical Botox interval. Fewer appointments per year at a higher price per treatment.
Also called: daxibotulinumtoxinA, daxxify injections, long lasting botox
Daxxify arrived as the first genuinely new idea in neuromodulators in years: a formulation that lasts longer. Where Botox, Dysport, Xeomin, and Jeuveau all settle around three to four months, Daxxify’s approval trials showed a median of about six for frown lines, and its stabilizer is a synthetic peptide rather than the human-derived albumin the other brands use. For people who have been booking a neuromodulator appointment every quarter for a decade, that is a meaningful change.
What it does
The mechanism is the same as every product in the class. Injected into the frown muscles, forehead, or crow’s feet, it blocks the nerve signal, the muscle relaxes, and the lines soften over two weeks. The difference is duration: most patients see four to six months before movement fully returns, versus three to four with other brands. The longer effect comes with a longer commitment; a heavy brow from imperfect placement also lasts longer, which is the main reason to choose an injector who has used Daxxify specifically.
The unit question
Daxxify units are not Botox units. The approved dose for frown lines is forty Daxxify units, treated as comparable to twenty of Botox. Clinics price per unit on the Daxxify scale, so a per-unit number that looks cheaper than Botox is not directly comparable. Ask for the total cost of the treatment and how long the injector expects it to last, then compare per year.
Who it suits
Regular users who want fewer appointments. People whose Botox has been wearing off at eight or ten weeks. Anyone who prefers a product without human or animal-derived components. It is also a reasonable first product, though many injectors like to establish a patient’s response on a shorter-acting brand first so that any placement adjustment does not have to be lived with for half a year.
What it costs
Frown lines typically run $400 to $600 per treatment, forehead and crow’s feet add to that, and a full upper face can approach a thousand dollars. Per visit that is more than Botox; per year it is often similar or less, because two or three visits replace three or four. The result for you decides the math.
Choosing an injector
Ask how long the injector has been using Daxxify and how its duration has held up in their patients. Ask how they handle a first-time patient. Ask for the total treatment price and the plan in Daxxify units. And ask to see results at two weeks and at four months, since the second photo is the one that distinguishes this product.
Browse the clinics below and compare Daxxify providers and pricing by city.
Why people choose Daxxify
Median duration around six months in approval trials, longer than any other brand
Peptide-stabilized, with no human albumin or animal proteins
Same treatment areas and technique as Botox
Two or three appointments a year instead of three or four
Are you a good candidate?
Regular neuromodulator users who want fewer appointments, people whose Botox wears off early, and anyone who prefers a product with no human or animal-derived components
By location
Find Daxxify near you
538 clinics across 217 cities list Daxxify on ClinicCompass. 377 of them (70%) say on their own websites that they offer financing or payment plans;
ask about approval and interest before you book.
In the approval trials for frown lines, the median time until lines returned to baseline was about six months, and a meaningful share of patients lasted longer. Real-world reports vary more; some injectors see five to six months consistently, others find it closer to four for certain patients. It reliably outlasts Botox for most people; how much longer is individual.
How is it dosed compared to Botox?
Daxxify units are its own scale and are not one to one with Botox. The approved frown line dose is forty Daxxify units, which is treated as comparable to twenty units of Botox. Clinics price per Daxxify unit accordingly, so compare total treatment cost, not the per-unit number.
Are there different side effects?
The profile matches other neuromodulators: occasional headache, bruising, and rarely a heavy brow or drooping lid from placement. Because the effect lasts longer, so does any placement issue, which makes injector experience with Daxxify specifically worth asking about.
What does it cost?
A frown line treatment commonly runs $400 to $600, higher than Botox per visit but often comparable or lower per year because there are fewer visits. The math depends on how long it lasts for you, which you only know after the first treatment.
Sources
Where this information comes from
Clinical facts on this page are checked against these primary sources.
1.DAXXIFY (daxibotulinumtoxinA-lanm) for injection, for intramuscular use: Prescribing Information, U.S. Food and Drug AdministrationFDA approval for moderate to severe glabellar lines at a 40-Unit dose (5 injections of 8 Units each); the boxed warning on distant spread of toxin effect; that DAXXIFY is formulated with a 35-amino-acid peptide excipient (RTP004) rather than human albumin; and that DAXXIFY's units cannot be compared to or converted into units of any other botulinum toxin product.
3.Neuromodulators, American Society for Dermatologic SurgeryConfirms the shared neuromodulator mechanism (injected into the muscle to relax it and soften the overlying skin), minimal pain, and the shared side effect profile (soreness, bruising, temporary muscle weakness, headache, drooping eyelid) that this page says Daxxify has in common with other brands.
4.Botulinum toxin therapy: FAQs, American Academy of DermatologyConfirms the roughly 3 to 4 month duration typical of other neuromodulator brands, the baseline this page contrasts with Daxxify's longer effect.
